By A Midwestern Doctor - Sunday, October 20, 2024
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Story at a Glance:
•DMSO is a remarkably safe substance that effectively treats a variety of conditions (e.g., chronic pain, acute injuries, and strokes) that medicine has struggled with for decades. Many readers here have already experienced profound benefits from using it.
•DMSO is a powerful (but safe) anti-inflammatory agent that is often extremely helpful for autoimmune conditions. For example, it’s frequently used to treat asthma, inflammatory bowel diseases (e.g., ulcerative colitis and irritable bowel syndrome), interstitial cystitis (painful bladder syndrome), ITP, lupus, multiple sclerosis, myasthenia gravis, scleroderma, Sjogren's syndrome, and uveitis.
•DMSO is also remarkably effective at stabilizing and refolding proteins. This allows it to treat a variety of “untreatable” genetic disorders, and conditions characterized by the abnormal accumulation of misfolded proteins in the body (e.g., amyloidosis) or chronic deposits of excessive contractile collagen (e.g., surgical scars, abdominal adhesions, Dupuytren’s contractures, and Peyronie’s disease). Two of the most dramatic examples of this are scleroderma and fibrodysplasia ossificans progressiva—both “untreatable” conditions where DMSO can provide truly lifesaving benefits.
•In this article, I will present the wealth of evidence substantiating each of those uses, share my theory on how the unusual antimicrobial properties of DMSO explain some of these benefits, and present DMSO treatment protocols for many of those disorders. Additionally, since many readers requested it, I put together a simplified guide on how to use DMSO orally or topically.
Note: over the last few days, I switched my focus to preventing an immensely unjust execution in Texas that shed light on how parents are often falsely accused of killing their babies after a vaccine death. Thanks in part to all of you speaking out, a miracle happened, the right people noticed (I can’t disclose what happened behind the scenes but consider this Tweet RFK Jr. put out which referenced a post referencing the article here) and a series of unprecedented actions happened to delay and possibly overturn an execution (which in reality was due to a baby dying from clearcut case of medical malpractice). This case still needs a great deal of support, so if you can contact either the governor (here) or the Texas legislators trying to overturn this (here and here) that would be immensely helpful.
Dimethyl sulfoxide (DMSO) is a simple and readily available naturally occurring chemical that rapidly enters the body through the skin and has a variety of remarkable therapeutic properties. When it was discovered, its proponents believed it (much like antibiotics) represented a new therapeutic principle in medicine and once adopted, would completely change how medicine was practiced. Unfortunately, the FDA conducted a reprehensible campaign against it and was able to successfully bury it.
Since there are so many uses for DMSO, to effectively present them, I’ve had to comb through well over ten thousand pages of scientific literature and then order them into a logical sequence (of what will be roughly a nine-part series). For instance, in the first part of this series, I discussed how DMSO completely changed the management of neurological injuries and showed that were it to be adopted, millions would no longer be disabled from the common emergencies we view as insurmountable within the current medical paradigm (e.g., frequent disabilities from stroke and the inevitability of becoming a paraplegic after a spinal cord injury).
DMSO and Protein Disorders
One of DMSO’s remarkable properties is its ability to function as a chemical chaperone and stabilize the three dimensional structure proteins assemble (fold) themselves into. This is important as many complex illnesses (e.g., many genetic disorders) result from misfolded proteins and presently can only be (ineffectively) managed with expensive drugs that aim to normalize the function of the abnormal proteins.
In turn, a few drugs have been developed to refold misfolded proteins, and to my knowledge, the most helpful ones on the market were the ones developed to treat cystic fibrosis (after the Cystic Fibrosis Foundation gave 150 million to bring these medications to market which currently are priced at roughly 300,000.00 a year). However, unlike the existing pharmaceutical chaperones (which are very specific to the misfolded protein), DMSO’s effect is remarkably universal.
Note: improving the physiologic zeta potential (as explained here) can also stabilize protein folding (while worsening it causes aggregation and misfolding).
Studies have shown DMSO can improve the functionality of the dysfunctional proteins that are seen in genetic disorders like cystic fibrosis,1 hereditary nephrogenic diabetes insipidus,1,2 Machado-Joseph disease,1 Niemann–Pick disease,1,2,3,4,5,6 and a defective protein that causes motor disorders and early death in mice.1 Likewise, it can also treat a variety of complex diseases which result from misfolded proteins damaging surrounding tissue.
For example, amyloidosis is a challenging condition that results from aggregates of insoluble proteins accumulating in the surrounding tissues. In turn, at least 39 studies and case reports have shown that DMSO can treat numerous types of amyloidosis (e.g., by solubilizing the amyloid aggregates and enabling the body to break down and eliminate them).
Likewise, DMSO has also been shown to revert the protein responsible for the devastating neurological prion diseases Creutzfeldt-Jakob disease1 and scrapie1 (which suggests it could also be helpful for mad cow disease).
Note: the previously mentioned studies are discussed in more detail here.
Presently, numerous human studies have shown that DMSO can treat amyloidosis, and one showed that it treated Neiman-Pick’s disease. Additionally, DMSO in this and this animal study and in this human study has been shown to treat Alzheimer’s disease, another condition linked to misfolded proteins (along with another one where adults with a variety of different degenerative brain conditions were treated). Likewise, we’ve clinically observed Parkinson’s (another disease that can be linked to misfolded proteins) responds to treatment with DMSO, and recently, one reader here reported:
I ordered DMSO immediately after your first article appeared. I am now in the 4th week of testing DMSO for Parkinson's disease. [The initial dose I took was too high so I stopped] On the second day of the break my Parkinson's symptoms almost disappeared and I felt better than I had felt for ages. The biggest improvement was in relief from bradykinesia. After being slow for the past years, I suddenly became Mr Speedy. At [a lower] dose I get minor brain fog for about one hour and the benefits of DMSO for the rest of the day.
In terms of symptom response to DMSO, in these first 4 weeks, pain, speed and the range of movement were most improved, followed by stiffness. Tremor seems to take more time to respond but there are already subtle signs of improvement. I and my family have also noted improvements in a whole range of other symptoms: brighter facial expression, eye comfort (more irrigation), stronger voice, more energy, better left/right hand coordination (fewer typing errors when using computer keyboard) and improved handwriting. Most importantly, I have periods of feeling really good which were previously absent. I have no doubt that DMSO is doing something good.
Note: since many cancer causing proteins are misfolded proteins, it is thought that this may partly explain DMSO’s anticancer properties.
While I am very open-minded to unconventional medical ideas and knew DMSO could treat a variety of otherwise incurable neurological diseases (e.g., ALS), there was one thing I always had a bit of difficulty believing. DMSO allegedly had been shown to cure Down Syndrome, demonstrated both in three clinical trials (e.g., this one and this one) and numerous remarkable case reports that were presented by multiple corroborating medical witnesses in Congressional testimony, along with numerous studies showing DMSO improved the cognition and behavior of developmentally delayed children. To explain this impossible benefit, I theorized it was likely due to DMSO’s protein stabilizing benefits, as Down Syndrome is characterized by “the aberrant accumulation of unfolded/misfolded proteins resulting from over-burdened protein quality control systems.”
In turn, one reader recently shared:
We’ve been giving some [DMSO] to our young daughter who has Down Syndrome. We've been giving her extra vitamins based on the treatment protocol of some studies that I found after reading your previous posts on this topic.
Almost immediately we noticed that our little girl was sleeping better through the night, and she's become more verbal. She'll be 2 in less than a week and she suddenly seems like she wants to say words more intentionally now, even if we mostly can't understand them yet. Also, her appetite has improved substantially. She just seems more active, and that's really awesome!
What I find particularly noteworthy about this is that the “untreatability” of genetic disorders (which typically result from a dysfunctional protein) has justified spending incredible amounts of money on both research and treatments for them (e.g., the industry is still in its early stages but 20.4 billion is already spent each year on gene therapies in the United States—which in part explains why there was such a push to bring the unsafe mRNA platform onto the market and open up a massive new drug sector). In contrast, DMSO is virtually free and has been shown to treat many of these disorders we still do not have a good option for.
Collagen Disorders
Irregular depositions of collagen underlie many different diseases (e.g., many rheumatologic disorders and many degenerative results of aging). Fortunately, much in the same way DMSO can address the accumulation of abnormal proteins, it can also address a variety of collagen disorders by “softening” collagen. For example, in a recent article I highlighted how, in addition to DMSO aiding the healing of chronic wounds and surgical scars, it:
•Attenuate excessive MMP-9 activity (which when excessive creates disordered healing and is linked to a variety of fibrotic diseases).
•Decreases experimentally induced intestinal adhesions (a common complication of abdominal surgeries) and eliminates subcutaneous radiation-induced fibrosis (the pathologic deposition of collagen).
•Disrupt the links between collagen fibers and treats keloid scars by flattening and loosening their associated collagen bundles (a result also found in this study of ten patients with keloid scars).
•Strengthens the tensile strength of healing surgical incisions and post-surgical scars and prevents hypertrophic (excessive) post-surgical scar formation.
Beyond all of this being incredibly beneficial for surgical outcomes and preventing (the fairly common) chronic complications of surgery, it (along with DMSO’s previously mentioned ability to eliminate abnormal protein deposits) also indicates DMSO can help with other collagen disorders.
In turn, the earliest study I know of that found a benefit in collagen disorders was this 1965 study, which reported that over three months of treatment, 5 out of 4 patients with scleroderma had an improved range of motion and softening of their skin, while 3 out of 3 patients with a Dupuytren’s contracture had a reduction in plaque size in the palmar fascia and increased finger motion.
Note: many other reports of DMSO benefitting collagen disorders (e.g., this symposium which provided data on 9,521 patients with a variety of conditions such as Dupuytren's contractures) also exists.
DMSO and Contractures
Dupuytren’s contractures occur when the collagen under the palm builds up and abnormally thickens.
A variety of treatment options exist to address this issue (e.g., injecting an enzyme to digest the collagen, breaking the collagen up with a needle, or surgically removing it), but all have downsides (e.g., complications from the procedure or a recurrence of the contracture). In turn, there is still insufficient evidence to build a consensus on the best way to approach this common condition.
Before the FDA shut down DMSO, this is what Merck reported to their clinical investigators (after roughly 4,000 patients had received DMSO for up to 18 months):
Dupuytren’s contracture—Long-term administration has caused some improvement in fibrous scar contractures. 90 percent is recommended.
In addition to the study mentioned above where 3 out of 3 patients with Dupuytren’s contracture improved from DMSO, another study gave DMSO to 29 patients with Dupuytren’s contracture and found 2 had a complete remission, 14 had a partial remission, and 13 had no response (along with a single patient with a Cicatricial contracture who had a partial remission).
In another study, DMSO yielded good results for 6 out of 9 Dupuytren’s contractures (and 1 out of 3 Peyronie's disease).
Conversely, in another trial of 23 patients with Dupuytren’s contractures that had been present for over 5 years, receiving 80% DMSO 3 times a day for a month did not help any of them. This suggests that DMSO works best early in the disease process, that a month is not long enough to get results, and that 90% rather than 80% may be necessary for this application.